ICEH Papers

NEW SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF FLUTAMIDE IN PHARMACEUTICAL PREPARATION USING CHROMOTROPIC ACID AS A COUPLING AGENT

Reddy, K.M., K. Suvardhan, K. Suresh, S. Prabhakar, P. Chiranjeevi “New Spectrophotometric Method For The Determination Of Flutamide In Pharmaceutical Preparation Using Chromotropic Acid As A Coupling Agent” in Martin J. Bunch, V. Madha Suresh and T. Vasantha Kumaran, eds., Proceedings of the Third International Conference on Environment and Health, Chennai, India, 15-17 December, 2003. Chennai: Department of Geography, University of Madras and Faculty of Environmental Studies, York University. Pages 410 – 416.

Abstract:

A rapid, selective, sensitive spectrophotometric method for the determination of flutamide (FLA) is described by the interaction of reduced flutamide in presence of potassium ferricyanide (K3[Fe(CN)6]) with chromotropic acid in basic medium. Absorbance of the resulting chromophore is measured at 465 nm and is stable for more than 7 days. The method is successfully employed for the determination of flutamide in pharmaceutical preparations, and common excipients, used as additives in pharmaceuticals, do not interfere in the proposed method. The method offers the advantages of simplicity, rapidity and sensitivity without the need for extraction.

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