Senior Research Scientist
Canadian
Action and Perception Network (CAPnet)
York Centre for Vision
Research
Education / Work Experience
1998~
Senior Research scientist, Centre for Vision Research, York University
1994~1998 Ph.D
Neuroscience, Dept. of Psychology, University of Sheffield , United Kingdom
1984~1992 Ophthalmologist, Dept. of Ophthalmology, The
2nd Affiliated Hospital, Shanxi Medical University, China
1979~1984 M.D. Medical Science,
Shanxi Medical University, China
Awards
1994~1997 ORS (Oversea Research
Student Awards Scheme),
Our research work focus on understanding how neurons in midbrain such as superior colliculus (SC), interstitial nucleus of Cajal (INC), rostral interstitial medial longitudinal fasciculus (riMLF) and cortical areas such as Supplementary Eye Field (SEF), Frontal Eye Field (FEF) and Lateral Intraparietal area (LIP) involve in control of the eye and head coordinate in 3-dimensionl gaze shift and how damage to these structure causes disturbances in eye or head posture and induces neurological disorders like torticollis and Parkinson’s disease. We are also studying frames of reference transformations for 3-D eye-head gaze control associated with SC, FEF, SEF and LIP and how they are influenced by cognition, in primate. The techniques we are using for studies include single unit / multiple units (array) recording, microstimulation and chemical inactivation of the brain areas while recording of 3-D eye and head movements.
FARSHADMANESH F, PYRNE P, WANG H, CORNEIL BD & CRAWFORD JD (2012 submitted) Relationships between neck muscles electromyography and the three-dimensional head kinematics during centrally-induced torsional head perturbations. Journal of Neurophysiology
MONTEON JA, Avillac M, Yan G, WANG H & CRAWFORD JD (2012 submitted) Neural mechanisms for predictive head movement strategies during sequential gaze shifts. Journal of Neurophysiology
FARSHADMANESH F, PYRNE P, KEITH GP, WANG H, CORNEIL
BD & CRAWFORD JD (2012, in press) Cross-validated models of the
relationships between neck muscle electromyography and three-dimensional head
kinematics during gaze behaviour. Journal of Neurophysiology 107:573-590
DESOUZA JFX, KEITH GP, YAN X, BLOHM G, WANG H &
CRAWFORD JD (2011) Intrinsic
reference frames of Superior Colliculus visuomotor receptive receptive
fields during Head-unrestrained gaze shifts. Journal of Neuroscience 31: 18313-18326
MONTEON JA, CONSTANTI AG, WANG H, MARTINEZ-TRUJILLO JC
& CRAWFORD JD (2010) Electrical stimulation of the Frontal Eye Fields in
the head-free macaque evokes kinematically normal 3D
gaze shifts. Journal
of Neurophysiology 104(6): 3462-3475
CONSTANTIN AG, MARTINES-TRUJILLO J, WANG H & CRAWFORD JD (2009) 3-D eye-head coordination in gaze shifts evoked during stimulation of Lateral Intraparietal cortex. Journal of Neuroscience 164(3): 1284 - 1302
KEITH GP, DESOUZA JFX, YAN X, WANG H & CRAWFORD JD (2009) A method for mapping response fields and determining intrinsic reference frames of single-unit activity: Applied to 3-D head unrestrained gaze shifts. Journal of Neuroscience Methods 180(1): 171-84
FARSHADMANESH F, CHANG P, WANG H, YAN X, CORNEIL BD & CRAWFORD JD (2008) Neck muscle synergies during stimulation and inactivation of the Interstitial Nucleus of Cajal (INC) Journal of Neurophysiology 100: 1677-1685
CONSTANTIN AG, MARTINES-TRUJILLO J, WANG H & CRAWFORD JD (2007) Frames of reference for gaze saccades evoked during stimulation of Lateral Intraparietal cortex. Journal of Neurophysiology 98(2): 696-709
FARSHADMANESH F, KLIER EM, CHANG P, WANG H & CRAWFORD JD (2007) Three dimensional eye-head coordination after injection of muscimol into the Interstitial Nucleus of Cajal (INC). Journal of Neurophysiology 97(3):2322-38
KLIER EM, WANG H & CRAWFORD JD (2007) The Interstitial Nucleus of Cajal encodes 3-D head orientations in Fick-like coordinates. Journal of Neurophysiology 97(1): 604-17
MONTEON JA, MARTINEZ-TRUJILLO JC, WANG H & CRAWFORD JD (2005) Cross-coupled adaptation of eye and head position commands in the primate gaze control system. Neuroreport 16(11): 1189-1192
MARTINEZ-TRUJILLO JC, MEDENDORP WP, WANG H & CRAWFORD JD (2004) Frames of reference for eye-head gaze commands in primate supplementary eye fields. Neuron 44(6): 1057-1066
CONSTANTIN AG, WANG H & CRAWFORD JD (2004) Role of superior colliculus in adaptive eye-head coordination during gaze shifts. Journal of Neurophysiology 92: 2168-2184
MARTINEZ-TRUJILLO JC, KLIER EM, WANG H & CRAWFORD JD (2003) Contribution of head movement to gaze command coding in monkey frontal cortex and superior colliculus. Journal of Neurophysiology 90: 2770-2776
MARTINEZ-TRUJILLO JC, KLIER EM, WANG H & CRAWFORD JD
(2003) Electrical stimulation of the Supplementary Eye Field in the head-free
macaque evokes kinematically normal gaze shifts. Journal of Neurophysiology, 89: 2961~2974
KLIER EM, WANG H, CRAWFORD JD (2003) Three-dimensional
eye-head coordination is implemented downstream from the superior colliculus. Journal
of Neurophysiology, 89: 2839~2853
KLIER EM, WANG H & CRAWFORD JD (2002)
Neural Mechanisms of three-dimensional eye and head movements. Annals
of the
KLIER EM, WANG H, CONSTANTI AG & CRAWFORD JD (2002)
Midbrain control of three-dimensional head orientation. Science, 295:
1316~1316
KLIER EM, WANG H & CRAWFORD JD (2001) The superior colliculus encodes commands in retinal coordinates. Nature Neuroscience, 4(6): 627~632
WANG S, WANG H, NIEMI-JUNOKLA U, WESTBY GWM, McHAFFIE J, STEIN B & REDGRAVE P (2000) A parallel
analysis of nociceptive neurons in rat superior colliculus using c-fos immunohistochemistry and electrophysiological under
different conditioned of anesthesia. The
Journal of Comparative Neurology,
425: 599~615
WESTBY GWM & WANG H (1997) A floating microwires method for electrophysiological stud in free moving animal. Journal of Neuroscience Methods, 76: 123~133
DU L, WANG M, CHAI J, WANG H, GUO R & GU X (1995)
Clinic study on treatment of amblyopia with colored
after-image method. Journal of Chinese strabismus and pediatrics
ophthalmology, 3 (2): 76~78
Abstracts:
Sadeh M, Wang H, Sajad A, Keith PG, Yan X and Crawford JD (2012) Visual and
motor coding
in the primate Superior Colliculus during
head-unrestrained gaze shifts. Society for Neuroscience 42, in press
Amir S, Yan XG, Wang H, and Crawford JD (2012) Visual and motor coding in the primate Frontal Eye Field during head-unrestrained gaze shifts. Society for Neuroscience 42, in press
Dash S, Yan XG, Wang
H, and Crawford JD (2011) Continuous remapping of superior colliculus visuospatial memory
responses during smooth pursuit eye movements. Society for Neuroscience 41,
18.02
Sadeh M, Wang H, Keith PG, and Crawford JD (2011) Visual and motor receptive fields in the Superior Colliculus during head-unrestrained gaze shifts. Society for Neuroscience 41, 489.15/QQ27
Farshadmanesh F, Byrne P, Yan X, Wang H, Corneil BD and Crawford JD (2011) A comparison between neck electromyography during voluntary torsional head movements and those evoked by unilateral stimulation and inactivation of the interstitial nucleus of Cajal. Society for Neuroscience 41, 699.18
Farshadmanesh F, Byrne P, Yan X, Wang H, Corneil BD and Crawford JD (2010) Cross-validation technique for establishing predictive models of the relationships between neck muscle electromyography and 3-D head kinematics. Society for Neuroscience, 40, 676.7
Dash S, Radik R, Wang H, Yan X and Crawford JD (2010) Task dependent spatial updating of targets across smooth pursuit eye movements (SP) in rhesus monkeys. Society for Neuroscience, 40,582.2
Yan X, Aviliac M, Aacencio-Monte J, Wang H and Crawford JD (2010) Instruction-related saccade and head movement activity in superior colliculus units during planned sequences of head-unrestrained gaze shifts in the monkey. Society for Neuroscience, 40, 676.4
Tharani A, Wang H, DeSouza JFX and Crawford JD (2010) Eye-head coordination during reactive, volitional, and scanning gaze shifts. Society for Neuroscience, 40, 676.12
Farshadmanesh F, Byrne P, Yan X, Wang H, Corneil BD and Crawford JD (2009) Cross-validation technique for establishing predictive models of the relationships between neck muscle electromyography and 3-D head kinematics. Society for Neuroscience, 39, 851.9
Keith GP, DeSouza JDX, Yan X, Wang H and
Cradford JD (2008) Intrinsic reference frames for visuomotor receptive fields in head-free gaze shifts I:
Methods and simulations. Society for Neuroscience, 38, 263.5
DeSouza JFX, Keith GP, Yan X, Wang H
and Crawford JD (2008) Intrinsic reference frames for visuomotor
receptive fields in head-free gaze shifts II:
Radik R, Yan X, Wang H, DeSouza JFX and Crawford JD (2008), "Task dependent spatial updating of saccade targets during smooth pursuit", Society for Neuroscience, 38, 264.17
Farshadmanesh F, Keith, GP, Yan X, Wang H, Corneil BD & Crawford JD (2008) Neck muscle activation during gaze fixations in the monkey: 3-D postural fields and relationship to 3-D behavioral constraints. Society for Neuroscience, 38,263.9
Farshadmanesh F, Chang PF, Yan X, Wang H, Corneil BD & Crawford JD (2007) Position–dependent neck muscle activation during stimulation of the interstitial nucleus of Cajal (INC). Society for Neuroscience, 37, 178.9
Monteon JA, Wang H, Martinez-Trujillo JC and Crawford JD (2007) Regulation of the gain in eye-head gaze commands by frontal cortex. Vision Science Society
Monteon JA, Aviliac M, Wang H, Yan X and Craford JD (2007) Cognitive aspects of eye-head coordination: role of frontal eye fields and superior colliculus. Society for Neuroscience, 37, 19.9
DeSouza JFX, Blohm G,
Hoover AEN, Chan CYJ, Yan X, Wang H and Crawford JD (2007)
Monteon JA, Wang H,
Martinez-Trujillo JC and Crawford JD (2006) Microstimulation
of the Frontal Eye Filed Evokes Kinematically
Farshadmanesh F, Chang PF, Yan X, Wang
H, Corneil BD and Crawford JD. (2006) Neck muscle synergies during gaze fixation before and after
pharmacological inactivation of the interstitial nucleus of Cajal
(INC) in the primate. Society for Neuroscience, 36, 139.9
Klier EM, Farshadmanesh
F, Wang H and Crawford JD (2006) Fick
coordinates for head control in the interstitial nucleus of Cajal:
stimulation-evoked movements and patterns of torsional
head drift during inactivation. Society for Neuroscience, 36, 39.8
CRAWFORD JD, YAN X, WANG H, RADIK R and DESOUZA JFX (2006) Internal representation of motion parallax in the superior colliculus (SC) during passive head translations and saccades to targets in 3-D space. Society for Neuroscience, 36, 139.15/D80
DeSouza JFX, Yan X, Blohm
G, Wang H and Crawford JD (2006) Gaze position effects and
position-dependent motor tuning in primate superior colliculus
(SC) neurons during head-unrestrained visually guided movements. Society
for Neuroscience, 33, 211.1
DeSouza JFX, Yan X, Wang H and Crawford
JD (2005) Position-dependent motor tuning of superior colliculus
(SC) neurons in the head-unconstrained monkey. Society for Neuroscience,
35, 858.16
Monteon JA, Wang H, Martinez-Trujillo JC and Crawford JD (2005). Gaze shifts evoked by electrical stimulation of the frontal eye field in the head-free macaque. Society for Neuroscience, 35, 858.18
Farshadmanesh F, Chang PF, Wang H,
Klier EM and Crawford JD (2005) 3-D kinematics of eye
and head movement during pharmacological inactivation of the interstitial nucleus
of Cajal (INC) in the primate. Society
for Neuroscience, 35, 858.6
Chang PF, Farshadmanesh F, Yan X, Wang H, Crawford JD and Corneil BD (2005) Neck Muscle Recruitment Evoked by Micro-stimulation of the Primate Interstitial Nucleus of Cajal (INC). Society for Neuroscience, 35, 302.10
Constantin AG, Wang H, Martinez-Trujillo JC and Crawford JD (2005) Frames of reference for gaze shifts evoked during microstimulation of lateral intraparietal cortex (LIP). Society for Neuroscience, 35, 858.17
Constantin AG, Wang H Matinez-Trojillo JC and Crawford JD (2004) Properties of gaze shifts evoked by stimulating lateral intraparietal (LIP) cortex in the head-unrestrained monkey. Society for Neuroscience, 30, 186.8
Klier EM, Wang H and Crawford JD
(2003) The three-dimensional neural integrator uses effector-specific coordinate systems. Society for
Neuroscience, 29, 499.7
Constanti AG, Wang H and Crawford JD (2003) Neural mechanisms for context-dependent eye-head coordination strategies: role of parallel and serial pathways. Society for Neuroscience, 29, 499.15
Farshadmanes F, Wang H, Klier EM, Constanti AG and Crawford JD (2003) 3-D eye and head coordination during inactivation of the Interstitial Nucleus of Cajal (INC) in the primate. Society for Neuroscience, 29, 499.12
Matinez-Trujillo JC, Wang H and Crawford JD (2003) Macaque supplementary eye fields encodes gaze in head centered coordinates. Society for Neuroscience, 29, 555.2
Matinez-Trujillo JC, Wang H and Crawford JD (2003) Head-centered gaze coding in the SEF of macaques. Neural Control of Movement – 13th Annual Meeting
Matinez-Trujillo JC, Wang H, Klier EM and Crawford JD (2002) Gaze shifts evoked by electrical stimulation of the supplementary eye field in the macaque monkey. Society for Neuroscience, 28, 11.9
Klier
EM, Matinez-Trujillo JC, Wang H and
Crawford JD (2002) Head-free versus head-fixed electrical stimulation in the
supplementary eye field and the superior colliculus
of the macaque monkey. Society for Neuroscience, 28, 266.6
Monteon JA, Matinez-Trujillo
JC, Wang H and Crawford JD (2002) Adaptive cross-couple
between eye and head position commands within the gaze control system of the
monkey. Society for Neuroscience, 28,
266.7
Matinez-Trujillo JC, Klier EM, Wang H and Crawford JD (2002) Head movements contribute to visuospatial coding in the SEF and SC of macaques. Neural Control of Movement – 12th Annual Meeting, A-02.
Matinez-Trujillo JC, Klier EM, Wang H and Crawford JD (2002) Head-fixed versus head-free electrical microstimulation in the SEF and SC of macaques. Multisensory Interactions Subserving Orienting Behavior, A-3.
Klier EM, Wang H and Crawford JD
(2001) The primate midbrain possesses a neural
integrator for torsional and vertical head posture. Society
for Neuroscience, 27, 784.2
Klier EM, Wang H and Crawford JD
(2001) Three-dimensional eye-head coordination is implemented downstream from
the superior colliculus. Neurobiology of Eye
Movements: From Molecules to Behavior (A
Constanti AG, Wang H, Klier EM and Crawford JD (2001) Context-dependent
adaptation of eye-head coordination in gaze saccades evoked by superior colliculus stimulation. Society for Neuroscience, 27, 405
Klier EM, Wang H and Crawford JD (2001) Three-dimensional eye-head coordination is implemented downstream from the superior colliculus. Neural Control of Movement – 11th Annual Meeting
Klier EM, Wang H and Crawford
JD (2000) The superior colliculus
encodes two-dimensional commands for head-free gaze shifts in oculocentric coordinates. Society for Neuroscience,
26, 109.5
Crawford JD, Klier EM and Wang H (2000) Listing's and Donders' laws of the eye and head are coordinated downstream from the superior colliculus. Society for Neuroscience, 26, 109.6
Constantin AG, Wang H, Klier EM and Crawford JD (2000) Context-dependent adaptation of eye-head coordination in gaze saccades evoked by superior colliculus stimulation. Society for Neuroscience, 26, 744.17
Wang H, Klier EM and Crawford JD (1999) 3-D gaze control and head posture deficits during reversible inactivation of the primate interstitial nucleus of Cajal (INC). Society for Neuroscience, 25 (2), 1650
Klier EM, Wang H and Crawford JD (1999) Stimulation of the Interstitial Nucleus of Cajal (INC) produces torsional and vertical head rotations in Fick coordinates. Society for Neuroscience, 25 (2), 1650
Wang H and Westby GWM (1997) Electrophysiological studies of
the cerebellotectal projection in the behaving rat
using a floating microwire technique. Brain
Research Associate 14, 54