CHEM 2050
Biochemistry


LectureTopicsChapter
1 Introduction to Scott and Biochemistry
Water: The solvent of life
Auto-ionization and pH
Buffers (know the math!)
3
2 Proteins
The 20 amino acids
Acid/base considerations
The three (the book claims four) types of -R groups
Amide linkages
Peptides (Oxytocin and Vassopressin)
1°, 2°, 3°,and 4° of proteins
5
3 Lipids
Triglycerides
Saturated vs. Unsaturated
Cis vs. Trans
Soaps, Detergents, Surfactants
Fatty acids
11
4 Carbohydrates
Monosaccharides
Fisher, Hayworth, modern 3-D views of monosaccharides
Aldoses vs. Ketoses
Disacchrides
α and β linkages
β-Lactose
Polysacchrides - Starch, Glycogen and
Celluose
7
5 Enzymes
Stereospecific
Cofactors (Coenzymes, Vitamins)
Kinetics
Steady-state Approximation
Michaelis-Menten Equation
Inhibition (competitive vs. noncompetive)
6
6 Carbohydrate Metabolism
Glycolysis (selected mechanisms)
Investment Phase (Stage 1)
Glyceraldehyde-3-phosphate and
on to Pyruvate (Stage 2)
The Fate of Pyruvate
8
7 Review
The first test
3,5,6,7,8,11
8 Nitrogen Metabolism
Inhibition (competitive vs. noncompetive)
Neurotransmitters (dopamine,epinephine,serotonin...)
Agonists vs. Antagonists (morphine and Candice Pert)
14.1
9 Psychotropic drugs
QSAR
Anologs of neurotransmitters
MAOI (the mechanism)
SSRI (the mechanism)
No real chapter in the book, just class notes
(some stuff in ch 14)
10 DNA
Basic Structure
Phosphate - sugar backbone
Base pairing
Shape
Method of replication
14
11 DNA Transcription - RNA
DNA vs. RNA
Protein Synthesis
17.1, 18.1, 18.2, 19
12 Review
The second test
14,17,18,19
13 Virus!
RNA,DNA...Retro...
Mechanism of Reproduction
General Structure
17.3 and "Biochem in Perspect.
HIV
14 Hemoglobin/Myoglobin
Cooperative Binding
Allosteric Binding
5.4
15 "Don't Stress the Cows"
The Stress Response

In class notes
16 Vision Chemistry
Rhodopsin
Vitiman A
β-Carotene (conjugation)
In class notes
17 Beginning Photosynthesis
Chlorophyll
Light
13.1 and 13.2