DR. PENGFEI CHANG  

York Centre for Vision Research  

CIHR Group for Action and Perception

York University,
4700 Keele St., Toronto, Ontario, M3J 1P3 
CANADA
Tel: (416) 736-2100 x 33725
Fax: (416) 736-5857
Email: pengfei@yorku.ca


BIOGRAPHY:
Academic Degrees
2002        Ph.D. (neuroscience),  International Doctoral School/Center for Sensory-Motor Interaction, Aalborg University, Denmark
1997        Doctorate of Medicine (surgery), Beijing Neurosurgical Institute, Tiantan Hospital, Capital University of Medical Science, Beijing, China
1991       Master of Medicine (surgery), Dalian Medical University, China

Working experience
2004-present     Post-doct. at York Center for Vision Research, York University, Canada  
2003-2004        Post-doct. at University of Arkansas for Medical Science, USA
2002-2003        Neurosurgeon, at Neurosurgical Department of Aalborg Hospital, Denmark
1997-1999        Associated Professor, Neurosurgical Department, First Hospital of Dlian Medical University, China
1991-1994       Surgeon/lecturer, Neurosurgical Department, Second Hospital of Dalian Medical University, China

CURRENT RESEARCH PROJECT:
At present, my research project is focused on the role of interstitial nucleus of Cajal (INC) in controlling posture and movement of the head. INC has been extensively investigated as a neural integrator for eye movement, and recently it has been demonstrated that INC is also involved in vertical and torsional movement of the head. Imbalance of the input and damage to the INC evoked abnormal head posture and movements, which were quite similar to the symptoms of a human disease-torticollis.  However, it is not known how the INC control the head posture and movement. We use cut-edge techniques including  single unit, 3-D eye/head movement and multiple intramuscular EMG recording to investigate the neuro-physiological mechanisms of the INC  with respect to the controlling of the head posture and movement. Micro-stimulation and pharmacological inactivation of INC are applied to the primate to evoke imbalance of INC function in comparision of normal behavour. We are dedicate to clarify the mechnisms of head posture and movement by identifing the correlation between the activatity of INC neurons and the EMG activity in the neck muscles in push-pull manner during the controlling of head posture and movement. The hypothesis is that the head posture and  movement  driven by the neck muscles may be found closely correlated with the INC activity during normal status, stimulation and chemical inactivation of the INC. Imbalance of neck muscles activation induced by the impaired INC fuction may cause neurological deficit which is corresponding to the clinical syndrome-torticollis. This study will also greatly improve our understanding of the physiological mechanisms of  visuo-motor system and the neural mechanism of head control. Clinically, this study has significant implication for better understanding and treatment of human disease-torticollis.
PUBLICATIONS:
Thesis, works and chapters 

Peng Fei Chang. Cerebral processing of tonic pain in humans：EEG study in association with psychophysical assessment. Ph.D. thesis, Aalborg Uinversity. ISBN:87-90562-09-7, 2002.Denmark.

Peng Fei Chang, Hong-Jin Shiu, Zi Gang Lian. Atlas of neurosurgical anatomy. Liaoning Technological Press. 2001, Shengyang, China.

Peng Fei Chang. Experimental studies on the mechanisms of development of conscious status following midbrain injury. Doctoral thesis, Capital University of Medical Science, Beijing, China.

Peng Fei Chang. The treatment of severe intra-ventricular bleeding caused by hypertension. In: Xi Guang Chen, Ju Sheng Hou (eds). New therapeutic approach for hypertensive cerebral hemorrhage. Liaoning Technological Press. 1994, Sengyang, China.

Peer reviewed papers 

Peng Fei Chang, Lars Arendt-Nielsen, Andrew C.N Chen. Comparative Cerebral Responses to Warm versus Cold Stimulus in Man: EEG Power Spectra and Coherence. Int. J. Psychophysiol. 2004 (in press).

Peng Fei Chang, Lars Arendt-Nielsen, Thomas Graven-Nielsen, Peter Svensson, Andrew C.N. Chen. Comparative EEG activation to skin pain and muscle pain induced by capsaicin injection.  Int. J. Psychophysiol. 2004; 51(2): 117-126.

Peng Fei Chang, Lars Arendt-Nielsen, Thomas Graven-Nielsen, Andrew C.N. Chen. Psychophysical and EEG responses to repeated experimental muscle pain in humans: Pain intensity encodes EEG activity. Brain Res. Bull. 2003; 59: 533-543.

Peng Fei Chang, Lars Arendt-Nielsen, Andrew C.N Chen. Differential cerebral responses to aversive auditory arousal versus muscle pain: specific EEG patterns are associated with human pain processing. Exp. Brain Res 2002; 147: 387-393.

Peng Fei Chang, Lars. Arendt-Nielsen, Andrew. C.N. Chen, Dynamic changes and spatial correlation of EEG activities during cold pressor test in man, Brain Research Bulletin 2002; 57 (5): 667-675.

Peng-Fei Chang, Lars Arendt-Nielsen, Thomas graven-Nielsen, Peter Svensson, Andrew C.N. Chen. Different EEG topographic effects of painful and non-painful intramuscular stimulation in man. Exp. Brain Res. 2001; 141: 195-203. 

Peng-Fei Chang, Lars Arendt-Nielsen, Thomas graven-Nielsen, Peter Svensson, Andrew C.N. Chen. Topographic effects of tonic cutaneous nociceptive stimulation on human electroencephalograph.   Neurosci Lett. 2001; 305 (1): 49-52.

Jiajin Zhang, Jing Zhai, Pengfei Chang. Expression and localization of BDNFmRNA to neurons in the brain following midbrain reticular formation injury by insitu hybridization. (with English abstract) Journal of Capital University of Medical Sciences 2000; 21 (1): 5-8.

Peng Fei Chang, Chung Cheng Wang, Ying Zhang. Monitoring of relative EEG power after midbrain injury in cats. Chinese Journal of Clinical Neurosurgery 2000: 5 (1): 39.

Peng Fei Chang, Xi Guang Chen. A new bipolar coagulating and cutting sucker in      neurosurgery (technique report). Chinese Journal of Neurosurgery. 2000, 16: 264

Peng Fei Chang, Chung Cheng Wang, Ying Zhang, Guo Ming Luan, Shao Dong Zhang, Li Yan, Chao Xu. Changes of rCBF and NPY in cortex following midbrain damage and the therapeutic effects of YM-14673 on them. Chinese Journal of Trauma, 2000; 16 (4): 245.

Peng Fei Chang, Chung Cheng Wang, Ying Zhang. The experimental studies on the effects of midbrain reticular formation damage on the conscious status and vital signs. Journal of Chinese Emergency Medicine, 2000; 1: 16-7.

Peng Fei Chang, Chung Cheng Wang, Ying Zhang. Immunochemical study of the brain derived neurotrophic factor (BDNF) on the midbrain reticular formation damage in rats. Chinese Journal of Trauma. 1999; 16 (suppl.), 467.

Peng Fei Chang, Chungcheng Wang, Yin Zhang, Guo Ming Lua: Therapeutic effects of YM-14673 on the conscious status caused by midbrain damage. Chinese Journal of Neurosurgery.1999; (1) 24-26.

Peng Fei Chang, Shaohua Li: Cushing’s ulceration in ICU of Neurosurgery. Foreign Medical Science in Cerebrovascular Diseases.1999; 7(1): 19-21.

Peng Fei Chang, Chun Cheng Wang, Ying Zhang, Li Yan. The influence of Ibotenic Acid-induced damage of reticular formation on mental status and related factors in cats. 1999; 11 (10):584-586.

Peng Fei Chang, Chung Cheng Wang, Ying Zhang, Shao Dong Zhang. The effect of midbrain damage on the amino acid transmitter in cortex of rats. Journal of Brain and Nervous Diseases. 1999; 7 (3): 155-156.

Peng Fei Chang, Chung Cheng Wang, Ying Zhang, Shao Dong Zhang, Chao Xu. The effect of midbrain damage of the changes of rCBF and NPY in the cortex of rats. Chinese Critical Care Medicine. 1999;11(3): 173.

Peng Fei Chang, Gui De Zhao. The comparison and analysis of two different operation for chronic subdural hemotma. Journal of Dalian Medical University. 1999; 21 (2): 140-142.

Peng Fei Chang, Xi Guang Chen. The application of self-made bipolar coagulating cutter in neurosurgery. Journal of Chinese Clinical Neurosurgery. 1999; 4 (3): 47.

Peng Fei Chang, Chung Cheng Wang, Ying Zhang, Yu Ling Tan. Dynamic monitoring of EEG, BAEP and SEP after midbrain damage in cats.  Journal of Clinical Electroencelagraphy. 1999; 8(3):162-166.

Peng Fei Chang, Shaohua Li. Intravascular stenting therapy for cerebral ischemic diseases. Foreign Medicine in Cerebro-vascular Diseases.1998; Dec. 6 (6): 356-358.

Shaodong Zhang, Peng Fei Chang, Chao Xu.  Measurement of functional amino acid in cortex of rats by ACCQ-Tag high performance liquid chromatography. Journal of Capital University of Medical Sciences. 1998; 19 (1): 56-58. 

Peng Fei Chang, Chung Cheng Wang. Experimental models of brainstem ischemia. Foreign Medicine in Cerebro-vascular Diseases.1997; 5(2): 67-70.

Peng Fei Chang, Chung Cheng Wang.  Clinical and neuro-electrophysiological evaluation of coma following severe brain damage. Foreign Medicine in Neurology & Neurosurgery 1997.24 (4) 202-204. 

Peng Fei Chang, Chung Cheng Wang. The protective effect of TRH and it’s analogue on the CNS trauma. Foreign Medicine in Cerebrovascular Diseases.1997; 5 (5): 270-273.

Peng Fei Chang, Chung Cheng Wang. Laser Doppler flowmetry and its application in neurosurgery . Foreign Medicine in Cerebrovascular Diseases 1996; 4 (2). 95-97.

Peng Fei Chang, Xiguang Chen. Treatment of severe intraventricular hemorrhage by ventricular drainage and use of urine kinase. Journal of Dalian Medical University 1994; (3): 205~207.

Guide Zhao, Minghai Wei, Peng Fei Chang. Epidural cyst--3 cases report. Journal of Chinese Neurosurgery 1994; (3): 304-306.

Peng Fei Chang, Guide Zhao. Epidural cyst. Journal of Dalian Medical University.1994; 16 (1): 45.

Abstract and internation communication

Peng Fei Chang, Lars Arendt-Nielsen, Thomas Graven-Nielsen, Peter, Svensson Andrew CN Chen. EEG and human pain: Topographic mapping of tonic pain by intradermal vs. intramuscular injection of capsaicin. Pain In Europe III, advances in pain research and therapy, Nice, France, 26-29, Sept. 2000. P.187.

Peng Fei Chang and Andrew CN Chen. Neurosurgical management of pain in China: an overview. Pain In Europe III, advances in pain research and therapy, Nice, France, 26-29, Sept. 2000. P.361.

Andrew CN Chen, Peng Fei Chang, Lars Arendt-Nielsen. EEG and human pain: Topographic mapping of EG power density in tonic clod pain using an universal Cola glass cold bottle test. NeuroImage 11, Sixth Annual Meeting of the Organization for human brain mapping, June 12-16, 2000, San Antonio, Texas USA p. S734.

Andrew CN Chen, Peng Fei Chang, Lars Arendt-Nielsen. New perspective of the dynamic analyses of cerebral evoked potentials: 3 D views, spatial co-ordinates, Isolation of activation extrema, and quantification of the field magnitude. NeuroImage 11, Sixth Annual Meeting of the Organization for human brain mapping, June 12-16, 2000, San Antonio, Texas USA p. S735

Chang P.F., Arendt-Nielsen L, Chen ACN. Dynamic changes and correlation between pain rating, skin temperature and EEG activaties during tonic cold pain. in A.W. Toga, R.S. Frackowiak and J.C. Mazziotta (Eds.)  Neuroimage. 7th annual meeting of the organization for human brain mapping, June 10-14, Brighton, UK.   2001, S870

Chang P.F., Arendt-Nielsen L, Graven-Nielsen T, Svensson P, Chen ACN. The effects of cutaneous nociception on EEG topographiy in A.W. Toga, R.S. Frackowiak and J.C. Mazziotta (Eds.)  Neuroimage. 7th annual meeting of the organization for human brain mapping, June 10-14, Brighton, UK. 2001; S870.

Chang P.F., Arendt-Nielsen L, Chen ACN. Post-stimulus effect of EEG induced by non-nociceptive and nociceptive stimuli. Abstract book for 25th annual SASP meeting, 4th-7th, April, Aalborg, Denmark, 2002; pp. 52. 

Chang P.F., Arendt-Nielsen L, Graven-Nielsen T, Chen ACN. Brain processing of cool and warm perceptions: EEG spectral topography and coherence anaylsis. NuroImage Human Brain Mapping 2002 Meeting, 2-6, June, 2002, Sendai, Japan. No. 731.

Chang P.F., Arendt-Nielsen L, Graven-Nielsen T, Chen ACN.  Differential cerebral responses to auditory aversive arousal and muscle pain: EEG topography and power spectra. NuroImage Human Brain Mapping 2002 Meeting, 2-6, June, 2002, Sendai, Japan. No. 732.

Chen ACN, Chang PF, Liu FJ, Arendt-Nielsen L. 3D brain mapping and source imaging of tonic cold pain: An universal Coca-Cola cold bottle test. NeuroImaging Human Brain Mapping 2003 Meeting, New York.

Chen ACN, Chang PF, Arendt-Nielsen L, Zanow F. 3D brain coherence mapping of tonic cold pain. NeuroImaging Human Brain Mapping 2003 Meeting, New York.

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