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Paper of the month (August 2020) from Dr. Perry's research group

Paper of the month (August 2020) from Dr. Perry's research group

Hughes MC, Ramos SV, Turnbull PC, et al. Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy. J Physiol. 2020;598(7):1377-1392. doi:10.1113/JP277306

Significance of the research:

98% of patients with Duchenne muscular dystrophy (DMD) develop cardiomyopathy, with 40% developing heart failure. Using mice, the study by Hughes and Ramos et al found that the energy-producing parts of cells known as ‘mitochondria’ begin to fail at very early stages of this disease before the hearts become dysfunctional. This discovery suggests that mitochondria may be a therapeutic target for the treatment of cardiomyopathy in DMD.

Click here to view a PDF document of this article.