MHRC News
Paper of the month (May 2021) from Dr. Olasunkanme (Ola) Adegoke's research group
Mann, G., & Adegoke, O. (2021). Effects of ketoisocaproic acid and inflammation on glucose transport in muscle cells. Physiological reports, 9(1), e14673. https://doi.org/10.14814/phy2.14673 Significance of the research: Type 2 diabetes and cardiovascular diseases affect millions of people world-wide, with the attending implications for morbidity and mortality. An underlying cause of these diseases is insulin resistance, especially skeletal […]
Paper of the month (April 2021) from Dr. Ronald Ceddia's research group
Da Eira, D., Jani, S., Sung, H., Sweeney, G., & Ceddia, R. B. (2020). Effects of the adiponectin mimetic compound ALY688 on glucose and fat metabolism in visceral and subcutaneous rat adipocytes. Adipocyte, 9(1), 550–562. https://doi.org/10.1080/21623945.2020.1817230 Significance of the research: Adiponectin is an adipose-derived hormone that is significantly reduced in the blood of obese and type 2 diabetic […]
Paper of the month (March 2021) from Dr. Heather Edgell's research group
Nardone M, Guzman J, Harvey PJ, Floras JS, Edgell H. Effect of a neck compression collar on cardiorespiratory and cerebrovascular function in postural orthostatic tachycardia syndrome (POTS). J Appl Physiol (1985). 2020;128(4):907‐913. doi:10.1152/japplphysiol.00040.2020 Significance of the research: Postural orthostatic tachycardia syndrome (POTS) is marked by an excessive increase of heart rate in the upright posture […]
Paper of the month (February 2021) from Dr. Peter Backx's research group
Zhao Y, Rafatian N, Backx PH, et al. Engineering microenvironment for human cardiac tissue assembly in heart-on-a-chip platform. Matrix Biol. 2020;85-86:189-204. doi:10.1016/j.matbio.2019.04.001 Significance of the research The generation of heart tissues from pluripotent stem cells is hampered by the lack of cellular maturation as well as problems with cellular composition. In addition to cardiomyocytes, […]
Professor Michael Riddell will be a presenter at Celebrating the 100th Anniversary of the Discovery of Insulin: Diabetes Research and Innovation in the Making
Insulin, the most important hormone for the control of metabolism in the body, was discovered 100 years ago by Fredrick Banting, Charles Best and James Collip under the directorship of Professor John Macleod at the University of Toronto. The discovery of insulin earned Banting and Macleod the Nobel Prize in 1923, and people around the […]