Theriau CF & Connor ML. Voluntary physical activity counteracts the proliferative tumor growth microenvironment created by adipose tissue via high-fat diet feeding in female rats. Physiol Rep. 2017, July, 5(13): e13325. Significance of the research: "Breast cancer is a multi-factoral disease that is impacted by many modifiable risk factors, including adopting a healthy lifestyle. Obesity […]
Kim, Y and Hood DA. Regulation of the autophagy system during chronic contractile activity-induced muscle adaptations. Physiol Rep. 2017, 5 (14), e13307. Significance of the research: "As skeletal muscle comprises a majority of body mass, the mitochondria within this tissue are of paramount importance in maintaining the metabolic status of an individual. Regular exercise training […]
Nwadozi E, Roudier E, Rullman E, Tharmalingam S, Liu HY, Gustafsson T, Haas TL. Endothelial FoxO proteins impair insulin sensitivity and restrain muscle angiogenesis in response to a high-fat diet. FASEB J. 2016 Sep;30(9):3039-52. Significance of the research: "Impaired insulin responsiveness of skeletal muscle can have a profound influence on the development of Type-2 diabetes. […]
Moghei M, Tavajohi-Fini P, Beatty B, Adegoke OA. Ketoisocaproic acid, a metabolite of leucine, suppresses insulin-stimulated glucose transport in skeletal muscle cells in a BCAT2-dependent manner. Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C518-27. Significance of the research: "Dietary protein and amino acids have many important functions in the body, including regulation of body weight, […]
Kolahdouzan M, Hamadeh MJ. The neuroprotective effects of caffeine in neurodegenerative diseases. CNS Neurosci Ther. 23(4) 272-290, 2017. Significance of the research: "Caffeine is the most widely used psychostimulant in Western countries. In Alzheimer’s disease, caffeine is beneficial in both men and women, in humans and animals. Similar effects of caffeine were observed in men […]
Sepa-Kishi DM, Wu MV, Uthayakumar A, Mohasses A, Ceddia RB. Anti-lipolytic and anti-lipogenic effects of the CPT-1b inhibitor oxfenicine in the white adipose tissue of rats. Am J Physiol Regul Integr Comp Physiol. 311: R779–R787, 2016. Significance of the research: "Obesity is commonly thought of as a disease where there is an energy imbalance resulting […]
Teich T, Dunford EC, Porras DP, Pivovarov JA, Beaudry JL, Hunt H, Belanoff JK, Riddell MC. Glucocorticoid antagonism limits adiposity rebound and glucose intolerance in young male rats following the cessation of daily exercise and caloric restriction. Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E56-68. Significance of the research: "Weight regain following successful weight loss […]