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Faculty Publications

  • Zangiabadi, & Abdul-Sater, A. A. (2022). Regulation of the NLRP3 Inflammasome by Posttranslational Modifications. The Journal of Immunology (1950), 208(2), 286–292. https://doi.org/10.4049/jimmunol.2100734
  • Edilova, Law, J. C., Zangiabadi, S., Ting, K., Mbanwi, A. N., Arruda, A., Uehling, D., Isaac, M., Prakesch, M., Al-awar, R., Minden, M. D., Abdul-Sater, A. A., & Watts, T. H. (2021). The PKN1- TRAF1 signaling axis as a potential new target for chronic lymphocytic leukemia. Oncoimmunology, 10(1), 1943234–1943234. https://doi.org/10.1080/2162402X.2021.1943234
  • Dhillon B, Aleithan F, Abdul-Sater Z, Abdul-Sater AA. The Evolving Role of TRAFs in Mediating Inflammatory Responses. Front Immunol. 2019;10:104. Published 2019 Feb 4. doi:10.3389/fimmu.2019.00104
  • Bishop GA, Abdul-Sater AA, Watts TH. Editorial: TRAF Proteins in Health and Disease. Front Immunol. 2019;10:326. Published 2019 Feb 26. doi:10.3389/fimmu.2019.00326
  • Ojcius DM, Jafari A, Yeruva L, Schindler CW, Abdul-Sater AA. Dicer regulates activation of the NLRP3 inflammasome. PLoS One. 2019;14(4):e0215689. Published 2019 Apr 23. doi:10.1371/journal.pone.0215689
  • Edilova MI, Abdul-Sater AA, Watts TH. TRAF1 Signaling in Human Health and Disease. Front Immunol. 2018;9:2969. Published 2018 Dec 18. doi:10.3389/fimmu.2018.02969
  • Chang YH, Wang KC, Chu KL, Clouthier DL, Tran AT, Torres Perez MS, Zhou AC, Abdul-SaterAA, Watts TH. Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity. Immunity. 2017. 47(5):943-958.e9. doi: 10.1016/j.immuni.2017.10.014
  • Abdul-Sater AA, Edilova MI, Clouthier DL, Mbanwi A, Kremmer E, Watts TH. The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease. Nature Immunology 2017 Jan;18(1):26-35.

  • Cheng, & Hawke, T. J. (2021). Wasting away: AJP-Cell Physiology initiates thematic reviews on skeletal muscle wasting. American Journal of Physiology: Cell Physiology, 321(1), C38–C39. https://doi.org/10.1152/ajpcell.00165.2021
  • Cheng, A.J., Chaillou, T., Kamandulis, S., Subocius, A., Westerblad, H., Brazaitis, M., Venckunas, V. (2020). Carbohydrates do not accelerate force recovery after glycogen-depleting followed by high-intensity exercise in humans. Scandinavian Journal of Medicine & Science in Sports. DOI:10.1111/sms.13655.
  • Cheng, A.J., Jude, B., Lanner, J.T. (2020). Intramuscular mechanisms of overtraining. Redox Biology. DOI:10.1016/j.redox.2020.101480.
  • Glass, L.D., Cheng, A.J., MacIntosh, B.R. (2020). Calcium sensitivity during staircase with sequential incompletely fused contractions. Journal of Muscle Research and Cell Motility. DOI:10.1007/s10974-019-09572-4.
  • Bruton, J.D., Cheng, A.J., Westerblad, H. (2020). Measuring Ca2+ in Living Cells. Advances in Experimental Medicine and Biology. 1131:7-26.
  • Olsson, K., Cheng, A.J., Al-Ameri, M., Wyckelsma, V.L., Rullman, E., Westerblad, H., Lanner, J.T., Gustafsson, T., Bruton, J.D. (2020). Impaired sarcoplasmic reticulum Ca2+ release is the major cause of fatigue-induced force loss in intact single fibres from human intercostal muscle. The Journal of Physiology. DOI: 10.1113/JP279090.
  • Ferreira, D.M.S., Cheng, A.J., Agudelo, L.Z., Cervenka, I., Chaillou, T., Correia, J.C., Porsmyr-Palmertz, M., Izadi, M., Hasson, A., Martinez-Redondo, V., Valente-Silva, P., Pettersson-Klein, A.T., Estall, J.L., Robinson M.M., Nair, S.K., Lanner, J.T., Ruas, J.L. (2019). LIM and Cysteine-rich Domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force. Skeletal Muscle. 9(1): 26.
  • Pedersen, K.K., Cheng, A.J., Westerblad, H., Olesen, J.H., Overgaard, K. (2019). Moderately elevated extracellular [K+] potentiates submaximal force and power in skeletal muscle via increased [Ca2+]i during contractions. American Journal of Physiology-Cell Physiology. 317(5):C900-C909.
  • Cheng, A.J., Hwee, D., Kim, L., Durham, N., Hinken, A., Kennedy, A., Terjung, R., Jasper, J., Malik, F., Westerblad, H. (2019). Fast skeletal troponin activator CK-2066260 increases fatigue resistance by reducing the energetic cost of muscle contraction. The Journal of Physiology. 597(17):4615-4625.
  • Steinz, M., Persson, M., Aresh, B., Cheng, A.J., Ahlstrand, E., Lilja, M., Lundberg, T.R., Rullman, E., Ängeby Möller, K., Sandor, K., Ajeganova, S., Yamada, T., Beard, N., Karlsson, B.C.G., Tavi, P., Kenne, E., Svensson, C.I., Rassier, D., Karlsson, R., Gustafsson, T., Lanner, J.T. (2019). Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis. JCI Insights. 28:5. doi:10.1172/jci.insight/126347.
  • Cheng, A.J., Allodi, I., Chaillou, T., Ivarsson, N., Schlittler, M., Lanner, J.T., Thams, S., Hedlund, E., Andersson, D.C. (2019). Intact single fibres from SOD1G93A ALS mice display preserved specific force, fatigue resistance, and training-like adaptations. The Journal of Physiology. 597(12):3133-3146.
  • Chaillou, T., Cheng, A.J. (2019). Mechanisms of prolonged low-frequency force depression: in vivo studies get us closer to the truth. American Journal of Physiology – Regulatory and Integrative Physiology. 316(5):R502-R503.
  • Neyroud, D., Cheng, A.J. *, Donnelly, C., Bourdillon, N., Gassner, A., Geiser, L., Rudaz, S., Kayser, B., Westerblad, H., Place, N. (2019). Toxic doses of caffeine are needed to increase skeletal muscle contractility. American Journal of Physiology – Cell Physiology. 316(2):C246-C251. (*Co-first authored publication)
  • Ivarsson, N., Mattsson, C.M., Cheng, A.J., Bruton, J.D., Ekblom, B., Lanner, J.T., Westerblad, H. (2019). SR Ca2+ leak in skeletal muscle acts as an intracellular signal to increase fatigue resistance. The Journal of General Physiology. 151(4): 567-577.
  • Cheng, A.J., Place, N., Westerblad, H. (2018). Molecular basis for exercise-induced fatigue; the importance of strictly controlled cellular Ca2+ handling. Cold Spring Harbor Perspectives In Medicine. doi: 10.1101/cshperspect.a029710.
  • Marrelli, K., Cheng, A.J., Brophy, J.D., Power, G.A. (2018). Perceived versus performance fatigability in patients with rheumatoid arthritis. Frontiers in Physiology. Accepted 2018-09-13.
  • Curriculum Vitae – Arthur J. Cheng, Ph.D. Page 4 of 25
  • Glass, L., Cheng, A.J., MacIntosh, B.R. (2018). The role of calcium in changing active force during intermittent submaximal stimulation in intact single mouse muscle fibres. Pflügers Archiv – European Journal of Physiology. 470(8):1243-1254.
  • Cheng, A.J. (2018). Cooling down the use of cold-water immersion for post-exercise skeletal muscle recovery. Temperature. 5(2): 103-105
  • Cheng, A.J., Willis, S.J., Zinner, C., Chaillou, T., Ivarsson, N., Ortenblad, N., Lanner, J.T., Holmberg, H.C., Westerblad, H. (2017). Post-exercise recovery of contractile function and endurance in humans and mice is accelerated by heating and slowed by cooling skeletal muscle. The Journal of Physiology. 595(24):7413-7426
  • Cheng, A.J., Neyroud, D., Kayser, B., Westerblad, H., Place, N. (2017). Intramuscular contributions to low-frequency force potentiation induced by a high-frequency conditioning stimulation. Frontiers in Physiology. https://doi.org/10.3389/fphys.2017.00712
  • Cheng, A.J., Westerblad, H. (2017). Mechanical isolation, and measurement of force and myoplasmic free [Ca2+] in fully-intact single skeletal muscle fibers. Nature Protocols. 12, 1763-1776.
  • Millet, G.P., Debevec, T., Brocherie, F., Girard, O., Pailoux, V., Wüst, R.C., Degens, H., Zuo, L., He, F., Chaillou, T., Cheng, A.J., Kayser, B., Favier, F.B., Begue, G., Murray, A.J., Horscroft, J.A. (2017). Commentary on viewpoint: Human skeletal muscle wasting in hypoxia: a matter of hypoxic dose? Journal of Applied Physiology. 122(2): 409-411.
  • Hwee, D.T.*, Cheng, A.J.*, Hartman, J.J., Hinken, A.C., Lee, K., Durham, N., Russell, A.J., Malik, F.I., Westerblad, H., and Jasper, J.J. (2017). The Ca2+ sensitizer CK-2066260 increases myofibrillar Ca2+ sensitivity and submaximal force selectively in fast skeletal muscle. The Journal of Physiology. 595(5):1657-1670. (*Co-first authored publication)

  • Watson, McKinnon, A., Santino, N., Bassett-Gunter, R. L., Calleja, M., & Josse, A. R. (2021). Integrating needs-supportive delivery into a laboratory-based randomised controlled trial for adolescent girls with overweight and obesity: Theoretical underpinning and 12-week psychological outcomes. Journal of Sports Sciences, 39(21), 2434–2443. https://doi.org/10.1080/02640414.2021.1939948
  • Adebero T, McKinlay BJ, Theocharidis A, Root Z, Josse AR, Klentrou P, Falk B. Salivary and Serum Concentrations of Cortisol and Testosterone at Rest and in Response to Intense Exercise in Boys and Men. In press. Pediatric Exercise Science.
  • Beaudry KM, Ludwa IA, Thomas AM, Ward WE, Falk B, Josse AR. First-year university is associated with greater body weight, body composition and adverse dietary changes in males than females. PLoS One. 2019 Jul 3;14(7):e0218554.
  • Kouvelioti R, Kurgan N, Falk B, Ward WE, Josse AR, Klentrou P. Cytokine and Sclerostin Response to High-Intensity Interval Running versus Cycling. Med Sci Sports Exerc. 2019 Jun 25.
  • Thomas AM, Beaudry KM, Gammage KL, Klentrou P, Josse AR. Physical Activity, Sport Participation, and Perceived Barriers to Engagement in First-Year Canadian University Students. J Phys Act Health. 2019 Jun 1;16(6):437-446.
  • Bridge A, Brown J, Snider H, Nasato M, Ward WE, Roy BD, Josse AR. Greek Yogurt and 12 Weeks of Exercise Training on Strength, Muscle Thickness and Body Composition in Lean, Untrained, University-Aged Males. Front Nutr. 2019 Apr 30;6:55.
  • Kouvelioti R, LeBlanc P, Falk B, Ward WE, Josse AR, Klentrou P. Effects of High-Intensity Interval Running Versus Cycling on Sclerostin, and Markers of Bone Turnover and Oxidative Stress in Young Men. Calcif Tissue Int. 2019 Jun;104(6):582-590.
  • Kouvelioti R, Kurgan N, Falk B, Ward WE, Josse AR, Klentrou P. Biomed Response of Sclerostin and Bone Turnover Markers to High Intensity Interval Exercise in Young Women: Does Impact Matter? Res Int. 2018 Nov 1;2018:4864952.
  • Allison DJ, Beaudry KM, Thomas AM, Josse AR, Ditor DS. Changes in nutrient intake and inflammation following an anti-inflammatory diet in spinal cord injury. J Spinal Cord Med. 2018 Oct 2:1-10.
  • Timmons JA, Atherton PJ, Larsson O, Sood S, Blokhin IO, Brogan RJ, Volmar C, Josse AR, Slenzt C, Wahlestedt CR, Phillips SM, Phillips BE, Gallagher IJ, Kraus WE. A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease. Nucleic Acids Res. 2018 Jul 9. doi: 10.1093/nar/gky570.
  • Kouvelioti R, Josse AR, Klentrou P.  The effects of dairy consumption on body composition and bone properties in youth: a systematic review Kouvelioti, R., Josse, A. & Klentrou, P. Effects of dairy consumption on body composition and bone properties in youth: a systematic review Curr Dev Nutr 2017;1:e001214.
  • Dekker J, Nelson K, Kurgan N, Falk B, Josse AR, Klentrou P. Wnt Signaling-related Osteokines and Transforming Growth Factors Before and After a Single Bout of Plyometric Exercise in Child and Adolescent Females. Pediatr Exerc Sci. 2017 Nov 1;29(4):504-512.
  • Allison DJ, Gabriel DA, Klentrou P, Josse AR, Ditor DS. The influence of chronic inflammation on peripheral motor nerve conduction following spinal cord injury: A randomized clinical trial. Top Spinal Cord Inj Rehabil. 2017 Fall;23(4):377-385
  • Allison DJ, Josse AR, Gabriel DA, Klentrou P, Ditor DS. Targeting inflammation to influence cognitive function following spinal cord injury: a randomized clinical trial. Spinal Cord. 2017 Jan;55(1):26-32.
  • Borges, Cruz, M. M. A. da, Ricci-Vitor, A. L., Silva, P. F. da, Grace, S. L., & Vanderlei, L. C. M. (2022). Publicly versus privately funded cardiac rehabilitation: access and adherence barriers. A cross-sectional study. São Paulo Medical Journal, 140(1), 108–114. https://doi.org/10.1590/1516-3180.2020.0782.R1.31052021
  • Thomas, Gallagher, R., & Grace, S. L. (2021). Future-proofing cardiac rehabilitation: Transitioning services to telehealth during COVID-19. European Journal of Preventive Cardiology, 28(7), E35–E36. https://doi.org/10.1177/2047487320922926
  • Giannoccaro, Aggarwal, S., Grace, S., Campbell, T. S., Hauer, T., Arena, R., & Rouleau, C. R. (2020). Factors Associated With Attendance at a 1-yr Post–Cardiac Rehabilitation Risk Factor Check.
  • Santiago de Araújo Pio, Chaves, G. S., Davies, P., Taylor, R. S., Grace, S. L., & Taylor, R. S. (2019). Interventions to promote patient utilisation of cardiac rehabilitation. Cochrane Library, 2019(2), CD007131–CD007131. https://doi.org/10.1002/14651858.CD007131.pub4
  • Pesah, Supervia, M., Turk-Adawi, K., & Grace, S. L. (2017). A Review of Cardiac Rehabilitation Delivery Around the World. Progress in Cardiovascular Diseases, 60(2), 267–280. https://doi.org/10.1016/j.pcad.2017.08.007
  • Shanmugasegaram, S.*, & Grace, S.L. (2017). Depression screening and treatment recall in male and female cardiovascular disease inpatients: Association with symptoms one year later. Heart & Lung;46(3):153-158. pii: S0147-9563(17)30067-5. June.
  • Ali, S.*, Chessex, C., Bassett-Gunter, R., & Grace, S.L. (2017). Patient satisfaction with cardiac rehabilitation: Association with utilization, functional capacity, and heart-health behavior. Patient Preference and Adherence;11:821-830. https://www.dovepress.com/articles.php?article_id=32526
  • Ghisi, G.L.M.*, Britto, R., Servio, T.C., Santos, C.A., Coronado, R.F., Rivas-Estany, E., Santibanez, C., Gonzalez, G., Burdiat, G., Lopez-Jimenez, F., Herdy, A.H., & Grace, S.L. (2017). Perceptions of cardiology administrators about cardiac rehabilitation in South America and the Caribbean. Journal of Cardiopulmonary Rehabilitation and Prevention;37(4):268-273. July
  • Grace, S.L., Taherzadeh, G.*, Chang, I.S., Boger, J., Arcelus, A., Mak, S., Chessex, C., & Mihailidis, A. (2017). Perceptions of seniors with heart failure regarding autonomous zero-effort monitoring of physiological parameters in the smart-home environment. Heart & Lung;46(4):313-319. July/Aug. doi: 10.1016/j.hrtlng.2017.04.007
  • Bennett, A.L., Lavie, C.J., & Grace, S.L. Cardiac rehabilitation following acute coronary syndrome in women. (2017). Current Treatment Options in Cardiovascular Medicine, 19(8):57. (invited). August. http://rdcu.be/txoh
  • Ivers, N., Schwalm, J-D., Witteman, H.O., Presseau, J., Taljaard, M., McCready, T., Bosiak, B., Cunningham, J., Smarz, S., Desveaux, L., Tu, J.V., Atzema, C.L., Oakes, G.H., Isaranuwatchai, W., Grace, S.L., Bhatia, S., Natarajan, M.K., & Grimshaw, J.M. (2017).  Interventions Supporting Long-term adherence aNd Decreasing cardiovascular events (ISLAND): pragmatic randomized controlled trial protocol. American Heart Journal; 190:64-75. August.
  • Findlay, B.*, Oh, P., & Grace, S.L. (2017). Cardiac rehabilitation outcomes by ethnocultural background: Results from the Canadian Cardiac Rehab Registry. Journal of Cardiopulmonary Rehabilitation and Prevention;37(5):334-340. Sept. doi: 10.1097/HCR.0000000000000238
  • Baek, S., Park, H-W., Lee, Y., Grace, S.L., & Kim, W-S. (2017). Translation, cross-cultural adaptation and psychometric validation of the Korean-Language Cardiac Rehabilitation Barriers Scale. Annals of Rehabilitation Medicine;41(5):858-867. October.
  • Poffley, A., Thomas, E.*, Grace, S.L., Neubeck, L., Gallagher, R., Woodruffe, S., Keech, W., Niebauer, J., & O’Neil, A. (2017). A systematic review of cardiac rehabilitation registries. European Journal of Preventive Cardiology;24(15):1596-1609. October.
  • Moghei, M.*, Turk-Adawi, K., Isaranuwatchai, W., Sarrafzadegan, N., Oh, P., Chessex, C., & Grace, S.L. (2017). Cardiac rehabilitation costs. International Journal of Cardiology;244:322-32. (invited) October.
  • Santiago Pio, C.*, Marzolini, S., Pakosh, M., & Grace S.L. (2017). The effect of cardiac rehabilitation dose on mortality & morbidity: A systematic review and meta-regression analysis. Mayo Clinic Proceedings; 92(11):1644-1659. November. Cardiac Rehabilitation Dose, Mortality, and Morbidity
  • Somanader, D.S.*, Chessex, C., Ginsburg, L., & Grace, S.L. (2017). Quality and variability of cardiovascular rehabilitation delivery: Applying the Canadian quality indicators. Journal of Cardiopulmonary Rehabilitation and Prevention;37(6):412-420. November.
  • Bhattacharya, Shah, V., Oresajo, O., & Scimè, A. (2021). p107 mediated mitochondrial function controls muscle stem cell proliferative fates. Nature Communications, 12(1), 5977–5977. https://doi.org/10.1038/s41467-021-26176-0
  • Bhattacharya, & Scimè, A. (2020). Mitochondrial Function in Muscle Stem Cell Fates. Frontiers in Cell and Developmental Biology, 8, 480–480. https://doi.org/10.3389/fcell.2020.00480
  • Cantini, Di Franco, A., Mannelli, M., Scimè, A., Maggi, M., & Luconi, M. (2020). The Role of Metabolic Changes in Shaping the Fate of Cancer-Associated Adipose Stem Cells. Frontiers in Cell and Developmental Biology, 8, 332–332. https://doi.org/10.3389/fcell.2020.00332
  • Bhattacharya, & Scimè, A. (2019). Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer. Frontiers in Endocrinology (Lausanne), 10, 773–773. https://doi.org/10.3389/fendo.2019.00773
  • p107 Determines a Metabolic Checkpoint Required for Adipocyte Lineage Fates. Porras DP, Abbaszadeh M, Bhattacharya D, D’Souza NC, Edjiu NR, Perry CGR, Scimè A. Stem Cells. 2017 May;35(5):1378-1391. doi: 10.1002/stem.2576. Epub 2017 Feb 23.
  • Decreased transcriptional corepressor p107 is associated with exercise-induced mitochondrial biogenesis in human skeletal muscle. Bhattacharya D, Ydfors M, Hughes MC, Norrbom J, Perry CG, Scimè A. Physiol Rep. 2017 Mar;5(5). pii: e13155. doi: 10.14814/phy2.13155.
  • Liu, Bayer, J. D., Aschar-Sobbi, R., Wauchop, M., Spears, D., Gollob, M., Vigmond, E. J., Tsushima, R., Backx, P. H., & Chauhan, V. S. (2018). Complex interactions in a novel SCN5A compound mutation associated with long QT and Brugada syndrome: Implications for Na+ channel blocking pharmacotherapy for de novo conduction disease. PloS One, 13(5), e0197273–e0197273. https://doi.org/10.1371/journal.pone.019727
  • The impact of age and frailty on ventricular structure and function in C57BL/6J mice. Feridooni HA, Kane AE, Ayaz O, Boroumandi A, Polidovitch N, Tsushima RG, Rose RA, Howlett SE. J Physiol. 2017 Jun 15;595(12):3721-3742. doi: 10.1113/JP274134. Epub 2017 May 14.