Uchida C, Nwadozi E, Hasanee A, Olenich S, Olfert IM, Haas TL. Muscle-derived vascular endothelial growth factor regulates microvascular remodelling in response to increased shear stress in mice. Acta Physiol (Oxf). 2015 Jul;214(3):349-60. doi: 10.1111/apha.12463. Significance of the research: It is well established the muscle cells release factors that provide important information to the local […]
D'Souza DM, Trajcevski KE, Al-Sajee D, Wang DC, Thomas M, Anderson JE, Hawke TJ. Diet-induced obesity impairs muscle satellite cell activation and muscle repair through alterations in hepatocyte growth factor signaling. Physiol Rep. 2015 Aug;3(8). pii: e12506. doi: 10.14814/phy2.12506. Significance of the research: While it is well established, by our lab and others, that high […]
Adegoke OA, Bates HE, Kiraly MA, Vranic M, Riddell MC, Marliss EB. Exercise in ZDF rats does not attenuate weight gain, but prevents hyperglycemia concurrent with modulation of amino acid metabolism and AKT/mTOR activation in skeletal muscle. Eur J Nutr. 2015 Aug;54(5):751-9. Significance of the research: It is no longer news that the percentage of […]
"We are very proud of Ms. Dessi Zaharieva for being awarded a 2015 Vanier Scholarship. Her work on the management of blood glucose levels during exercise in patients with Type 1 diabetes has the potential to contribute to the development of the exercise-smart artificial pancreas. Her overarching goal is to help reduce the burden of […]
Brown RE, Sharma AM, Ardern CI, Mirdamadi P, Mirdamadi P, Kuk JL. Secular differences in the association between caloric intake, macronutrient intake, and physical activity with obesity. Obes Res Clin Pract. 2015 Sep 14. pii: S1871-403X(15)00121-0. doi: 10.1016/j.orcp.2015.08.007. Significance of the research: The prevalence of obesity has increased over time and it has been suggested […]
"A third-year York kinesiology PhD student was one of the torch carriers in the relay that opened the recently completed Toronto 2015 Pan Am Games..." [Click here for complete story]
Moghimi E, Solomon JA, Gianforcaro A, Hamadeh MJ. Dietary Vitamin D3 Restriction Exacerbates Disease Pathophysiology in the Spinal Cord of the G93A Mouse Model of Amyotrophic Lateral Sclerosis. PLoS One. 2015 May 28;10(5):e0126355. Significance of the research: Amyotrophic lateral sclerosis (ALS) is a debilitating neuromuscular disease that results in motor neuron degeneration. As a result, […]
Saleem A, Iqbal S, Zhang Y, Hood DA. Effect of p53 on mitochondrial morphology, import, and assembly in skeletal muscle. Am J Physiol Cell Physiol. 2015 Feb 15;308(4):C319-29. Significance of the research: The tumor suppressor protein p53 needs little introduction with respect to its abilities to serve as the Guardian of the Genome – for […]
Wales S, Hashemi S, Blais A, McDermott JC. Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling. Nucleic Acids Res. 2014 Oct;42(18):11349-62. Significance of the research: The goal of our lab is to understand the role of transcription factor MEF2 during development and disease. MEF2 (A-D) […]
Thomas MM, Trajcevski KE, Coleman SK, Jiang M, Di Michele J, O'Neill HM, Lally JS, Steinberg GR, Hawke TJ. Early oxidative shifts in mouse skeletal muscle morphology with high-fat diet consumption do not lead to functional improvements. Physiol Rep. 2014 Sep 17;2(9). Significance of the research: The incidence of type 2 diabetes mellitus (T2DM) […]