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Dr. Patricia Lakin-Thomas Faculty of Science
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Publications

  • Lakin-Thomas, P.L. (2023) The case for the TOR (Target of Rapamycin) pathway as a candidate circadian oscillator. International Journal of Molecular Sciences 24, 13307. doi: 10.3390/ijms241713307
  • Eskandari, R., Ratnayake, L. Lakin-Thomas, P.L. (2021) Shared components of the FRQ-less oscillator and TOR pathway maintain rhythmicity in Neurospora. J. Biol. Rhythms 36, 329–345. doi: 10.1177/0748730421999948
  • Lakin-Thomas, P.L. (2019) Circadian rhythms, metabolic oscillators, and the target of rapamycin (TOR) pathway: the Neurospora connection. Current Genetics 65(2): 339–349 [invited review] https://doi.org/10.1007/s00294-018-0897-6.
  • Ratnayake, L., Adhvaryu, K., Kafes, E., Motavaze K. and Lakin-Thomas, P.L. (2018) A component of the TOR (Target of Rapamycin) nutrient-sensing pathway is essential for circadian rhythmicity in Neurospora crassa. PLoS Genet 14(6): e1007457. doi:10.1371/journal.pgen.1007457.
  • Adhvaryu K., Firoozi G., Motavaze K., and Lakin-Thomas P.L. (2016) PRD-1, a component of the circadian system of Neurospora crassa, is a member of the DEAD-box RNA helicase protein family. J. Biol. Rhythms 31, 258-271
  • Lakin-Thomas, P.L. (2015) Nicholas Mrosovsky, A Remembrance. J. Biol. Rhythms 30, 359-363.
  • Lakin-Thomas, P.L., Bell-Pedersen, D. and Brody, S. (2011) The genetics of circadian rhythms in Neurospora. Ch. 3, The Genetics of Circadian Rhythms (Advances in Genetics/Volume 74) ed. S. Brody. Academic Press, Elsevier (Burlington), pp. 55-103. [invited book chapter]
  • Li, S., Motavaze, K, Kafes, E., Suntharalingam, S. and Lakin-Thomas, P.L. (2011) A new mutation affecting FRQ-less rhythms in the circadian system of Neurospora crassa. PLoS Genet 7(6): e1002151. doi:10.1371/journal.pgen.1002151
  • Khatun, R. and Lakin-Thomas, P.L. (2011) Activation and localization of protein kinase C in Neurospora crassa. Fungal Genet. Biol. 48. 465-473.
  • Li, S. and Lakin-Thomas, P.L. (2009) Effects of prd circadian clock mutations on FRQ-less rhythms in Neurospora. J. Biol. Rhythms 25, 71-80.
  • Schneider, K., Perino, S., Oelhafen, K., Li, S., Zatsepin, A., Lakin-Thomas, P.L. and Brody, S. (2009) Rhythmic conidiation in constant light in vivid mutants of Neurospora crassa. Genetics 181, 917-931.
  • Lakin-Thomas, P.L. (2006) Transcriptional feedback oscillators: Maybe, maybe not… J. Biol. Rhythms 21, 83-92. [invited review]
  • Lakin-Thomas, P.L. (2006) New models for circadian systems in microorganisms. FEMS Microbiol. Lett. 259, 1-6. [invited review]
  • Lakin-Thomas, P.L. (2006) Circadian clock genes frequency and white collar-1 are not essential for entrainment to temperature cycles in Neurospora crassa. Proc. Natl. Acad. Sci. USA 103, 4469-4474.
  • Lakin-Thomas, P. L. (2005) Circadian rhythms in Neurospora crassa: Beyond the frq gene. In: The Circadian Clock in Eukaryotic Microbes (F. Kippert, ed.) Landes Bioscience, Georgetown, TX. http://www.eurekah.com/abstract.php?chapid=2328&bookid=180&catid=85 [invited book chapter]
  • Gooch, V. D., Freeman, L. and Lakin-Thomas, P. L. (2004) Time-lapse analysis of the circadian rhythms of conidiation and growth rate in Neurospora. J. Biol. Rhythms 19, 493-503.
  • Lakin-Thomas, P. L. and Brody, S. (2004) Circadian rhythms in microorganisms: New complexities. Ann. Rev. Microbiol. 58, 489-519. [invited review]
  • Lakin-Thomas, P. L., Gooch, V. D. and Ramsdale, M. (2001) Rhythms of differentiation and diacylglycerol in Neurospora. Phil. Trans. R. Soc. Lond. B. 356, 1711-1715. [invited review]
  • Bell-Pedersen, D., Crosthwaite, S. K., Lakin-Thomas, P. L., Merrow, M. W. and Økland, M. (2001) The Neurospora circadian clock - Simple or complex? Phil. Trans. R. Soc. Lond. B. 356, 1697-1709. [invited review]
  • Ramsdale, M. and Lakin-Thomas, P. L. (2000) sn-1,2-Diacylglycerol levels in the fungus Neurospora crassa display circadian rhythmicity. J. Biol. Chem. 275, 27541-27550.
  • Lakin-Thomas, P. L. and Brody, S. (2000) Circadian rhythms in Neurospora crassa: Lipid deficiencies restore robust rhythmicity to null frequency and white-collar mutants. Proc. Natl. Acad. Sci. USA 97, 256-261.
  • Lakin-Thomas, P. L. (2000) Circadian rhythms: New functions for old clock genes? Trends in Genetics 16, 135-142. [invited perspective]
  • Lakin-Thomas, P. L. and Johnson, C. H. (1999) Commentary: Molecular and cellular models of circadian systems. J. Biol. Rhythms 14, 486-489. [invited commentary]
  • Lakin-Thomas, P. L. (1998) Choline depletion, frq mutations, and temperature compensation of the circadian rhythm in Neurospora crassa. J. Biol. Rhythms 13, 268-277.
  • Lakin-Thomas, P. L. (1998) Chapter 7: Circadian rhythmicity in Neurospora crassa. In: Biological Rhythms and Photoperiodism in Plants (P.J. Lumsden and A.J. Millar, eds.) BIOS Scientific Publishers, Oxford, pp. 119-134. [invited book chapter]
  • Lakin-Thomas, P. L. (1997) Commentary: Effects of photic and non-photic stimuli on melatonin secretion. J. Biol. Rhythms 12, 575-578. [invited commentary]
  • Lakin-Thomas, P. L., Brody, S. and Coté, G. G. (1997) Temperature compensation and membrane composition in Neurospora crassa. Chronobiol. Int. 14, 445-454. [invited review]
  • Lakin-Thomas, P. L. (1996) Effects of choline depletion on the circadian rhythm in Neurospora crassa. Biological Rhythm Res. 27, 12-30.
  • Coté, G. G., Lakin-Thomas, P. L. and Brody, S. (1996) Membrane Lipids and Circadian Rhythms in Neurospora crassa. In: Membranes and Circadian Rhythms (Th. Vanden Driessche, ed.) Springer-Verlag, Berlin, pp. 13-46. [invited review]
  • Lakin-Thomas, P. L. (1995) A beginner's guide to limit cycles, their uses and abuses. Biological Rhythm Res. 26, 216-232. [invited review]
  • Lakin-Thomas, P. L. (1993) Commentary: Strong or weak phase resetting by light pulses in humans? J. Biol. Rhythms 8, 348-350. [invited commentary]
  • Lakin-Thomas, P. L. (1993) Evidence against a direct role for inositol phosphate metabolism in the circadian oscillator and the blue-light signal transduction pathway in Neurospora crassa. Biochem. J. 292, 813-818.
  • Lakin-Thomas, P. L. (1993) Effects of inositol starvation on the levels of inositol phosphates and inositol lipids in Neurospora crassa. Biochem. J. 292, 805-811.
  • Lakin-Thomas, P.L. (1992) Phase-resetting of the Neurospora crassa circadian oscillator: Effects of inositol depletion on sensitivity to light. J. Biol. Rhythms 7, 227-239.
  • Lakin-Thomas, P.L., Brody, S. and Coté, G.G. (1991) Amplitude model for the effects of mutations and temperature on period and phase resetting of the Neurospora circadian oscillator. J. Biol. Rhythms 6, 281-297.
  • Lakin-Thomas, P.L. (1991) Temperature compensation of the circadian rhythm in Neurospora crassa: Comments on the vicinal water hypothesis. J. Biol. Rhythms 6, 181-183. [commentary]
  • Lakin-Thomas, P.L., Coté, G.G. and Brody, S. (1990) Circadian rhythms in Neurospora crassa: Biochemistry and genetics. Critical Reviews in Microbiology 17, 365-416. [invited review]
  • Brown, G.C., Lakin-Thomas, P.L. and Brand, M.D. (1990) Control of respiration and oxidative phosphorylation in isolated rat liver cells. Eur. J. Biochem. 192, 355-362.
  • Nobes, C.D., Lakin-Thomas, P.L. and Brand, M.D. (1989) The contribution of ATP turnover by the (Na+/K+)-ATPase to the rate of respiration of hepatocytes. Biochim. Biophys. Acta 976, 241-245.
  • Lakin-Thomas, P.L. and Brand, M.D. (1988) Stimulation of respiration by mitogens in rat thymocytes is independent of mitochondrial calcium. Biochem. J. 256, 167-173.
  • Lakin-Thomas, P.L. and Brand, M.D. (1987) Mitogenic stimulation transiently increases the exchangeable mitochondrial calcium pool in rat thymocytes. Biochem. J. 246, 173-177.
  • Lakin-Thomas, P.L. and Brody, S. (1986) Neurospora crassa mitochondria contain two forms of a 4'-phosphopantetheine-modified protein. J. Biol. Chem. 261, 4785-4788.
  • Lakin-Thomas, P.L. and Brody, S. (1985) A pantothenate derivative is covalently bound to mitochondrial proteins in Neurospora crassa. Eur. J. Biochem. 146, 141-147.
  • Lakin-Thomas, P.L. and Brody, S. (1985) Circadian rhythms in Neurospora crassa: Interactions between clock mutations. Genetics 109, 49-66.
  • “The TOR (Target of Rapamycin) pathway and circadian rhythmicity in Neurospora,” Patricia Lakin-Thomas, Sixth Conference of the Canadian Society for Chronobiology, June 2023 [invited Distinguished Lecture]
  • “The metabolic regulation of the TOR pathway in Neurospora crassa,” Maryam Fayyazi and Patricia Lakin-Thomas, The 4th Annual CanFunNet Fungal Biology Conference, online conference, May 2023 [flash talk presented by Maryam Fayyazi]
  • “The role of TOR (Target of Rapamycin) pathway in the circadian clock of Neurospora crassa,” Golnoush Akhtari and Patricia Lakin-Thomas, Ontario Cell Biology Symposium, Aug 2022 [poster]
  • “Localization and interaction of circadian clock and TOR Pathway components in Neurospora,” Rosa Eskandari and Patricia Lakin-Thomas, Ontario Cell Biology Symposium, Aug 2022 [poster]
  • “Localization and function of TOR Pathway components and their effects on circadian rhythmicity in the fungus Neurospora,” Rosa Eskandari, Lalanthi Ratnayake, Mingyu Lim, Pegah Ghorbani and Patricia Lakin-Thomas, Ontario Cell Biology Symposium, July 2021 [poster and flash talk presented by Rosa Eskandari]
  • “Shared components of the FRQ-less oscillator and TOR pathway maintain rhythmicity in Neurospora,” Rosa Eskandari, Lalanthi Ratnayake, Mingyu Lim, and Patricia Lakin-Thomas, 85th Cold Spring Harbor Laboratory Symposium on Quantitative Biology: Biological Time Keeping, online conference, June 2021 [virtual poster, presented by R. Eskandari]
  • “Role of the TOR (Target of Rapamycin) pathway in circadian rhythmicity of Neurospora crassa,” Rosa Eskandari, Lalanthi Ratnayake, and Patricia L. Lakin-Thomas, CanFunNet 2020, online conference, July 2020 [contributed short talk, presented by R. Eskandari]
  • “Mutual Components of FRQ-Less Oscillator and TOR Pathway Maintain TTFL Rhythmicity in Neurospora,” Rosa Eskandari, Lalanthi Ratnayake, and Patricia L. Lakin-Thomas, Society for Research on Biological Rhythms, online conference, June 2020 [virtual poster]
  • “Relationship between TOR (Target of Rapamycin) and non-TTFL circadian rhythmicity in Neurospora,” Rosa Eskandari, Milad Falahat Chian, Lalanthi Ratnayake, Wu Di, and Patricia Lakin-Thomas, The 1st Annual Ontario Cell Biology Symposium, Toronto, Canada, Aug 2019 [poster]
  • “Relationship between TOR (Target of Rapamycin) and non-TTFL rhythmicity in Neurospora,” Rosa Eskandari, Milad Falahat Chian, Lalanthi Ratnayake, Wu Di, and Patricia Lakin-Thomas, Fourth Conference of the Canadian Society for Chronobiology, Montreal, Canada, May 2019 [poster]
  • “TOR pathway components in the circadian system of Neurospora crassa,” Lalanthi Ratnayake, Chanhee Seo, Alexandra Pana, Aryan Lajevardi, Nicholas Chrobok, Avideh Khalili, Rosa Eskandari and Patricia Lakin-Thomas, Society for Research on Biological Rhythms, Amelia Island, Florida, USA, May 2018 [poster]
  • “Nutrient sensing through the RNA helicase PRD-1 in regulation of circadian rhythmicity in Neurospora crassa,” Di Wu, Milad Falahat Chian and Patricia Lakin-Thomas, Society for Research on Biological Rhythms, Amelia Island, Florida, USA, May 2018 [poster]