Tara L

	3D Network comprised of endothelial cells This figure shows skeletal muscle microvascular endothelial cells cultured in a three-dimensional collagen matrix. The cells elongate and form network connections with other endothelial cells in the matrix. We can then analyze gene expression and the role of specific signalling pathways required for the initiation of endothelial cell network formation.
	Cross-section of skeletal muscle Labeled with fluorescent antibodies to type IV collagen, which is a protein that forms the basement membrane surrounding muscle cells and capillaries More capillaries surrounding muscle fibers means better muscle endurance and improved health. What determines the number of capillaries around muscle fibers, and how can we increase this number?
	3D Network of endothelial cells This figure shows skeletal muscle microvascular endothelial cells cultured in a three-dimensional collagen matrix. The cells elongate and form network connections with other endothelial cells in the matrix. We can then analyze gene expression and the role of specific signalling pathways required for the initiation of endothelial cell network formation. These cells have been stained with fluorescein-phalloidin to demark the actin cytoskeleton.
	Skeletal muscle endothelial cells in culture These cells have been visualized using an antibody against endothelial nitric oxide synthase (gree) and a protein that binds to nuclei (blue), confirming their endothelial cell phenotype.

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